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Rank | Population | City | Alternative city name(s) | Country |
| 55,881 | Sa Dec | | Vietnam |
| 15,878 | Saalfelden am Steinernen Meer | | Austria |
| 181,543 | Saarbrücken | | Germany |
| 55,567 | Šabac | | Serbia |
| 182,133 | Sabadell | | Spain |
| 75,408 | Sabah as-Salim | | Kuwait |
| 9,141 | Sabana Grande | | Puerto Rico |
| 6,019 | Sabana Seca | | Puerto Rico |
| 21,168 | Sabanagrande | | Colombia |
| 68,494 | Sabanalarga | | Colombia |
| 33,940 | Sabaneta | | Colombia |
| 25,647 | Sabaneta | San Ignacio de Sabaneta | Dominican Republic |
| 19,822 | Sabanitas | | Panama |
| 126,806 | Sabará | | Brazil |
| 134,113 | Sabha | | Libya |
| 101,515 | Sabhar | Savar | Bangladesh |
| 7,738 | Sabi | | Gambia |
| 32,803 | Sabirabad | | Azerbaijan |
| 148,327 | Sabratah Surman | | Libya |
| 20,815 | Sabunçu | | Azerbaijan |
| 46,982 | Sabya | | Saudi Arabia |
| 214,165 | Sabzevar | | Iran |
| 136,746 | Sacaba | | Bolivia |
| 29,989 | Sacele | | Romania |
| 116,264 | Sacheon | Sach'on | South Korea |
| 66,910 | Šachrisabz | Shahrisabz | Uzbekistan |
| 39,328 | Šachtinsk | Shaktinsk | Kazakhstan |
| 224,211 | Šachty | | Russia |
| 21,831 | Šachunja | | Russia |
775 | 458,078 | Sacramento | | United States of America |
| 7,277 | Sada | | Mayotte |
| 60,487 | Sa'dah | | Yemen |
| 46,703 | Sadao | | Thailand |
| 206,933 | Sadiqabad | | Pakistan |
| 80,964 | Šadrinsk | | Russia |
| 27,890 | Safad | Zefat | Israel |
| 335,164 | Safi | | Morocco |
| 47,940 | Safonovo | | Russia |
| 35,404 | Safranbolu | | Turkey |
| 50,125 | Safwah | | Saudi Arabia |
| 167,099 | Saga | | Japan |
519 | 640,175 | Sagamihara | | Japan |
| 176,254 | Sagamu | | Nigeria |
| 248,330 | Sagar | | India |
| 52,964 | Sagar | | India |
| 12,191 | Sagaredzho | | Georgia |
| 66,637 | Sagay | | Philippines |
| 46,867 | Sagua la Grande | | Cuba |
| 56,821 | Sagunt | Sagunto | Spain |
| 41,922 | Sahab | | Jordan |
| 59,144 | Sahagún | | Colombia |
| 85,553 | Saham | | Oman |
726 | 487,066 | Saharanpur | | India |
| 146,644 | Saharsa | | India |
| 61,177 | Sahaswan | | India |
| 96,574 | Sahibganj | | India |
| 254,477 | Sahiwal | | Pakistan |
| 61,831 | Sahuayo de José María Morelos | | Mexico |
| 342,913 | Sai Kung | Tseung Kwan O | Hong Kong |
| 136,856 | Saïda | | Algeria |
| 134,744 | Saidpur | | Bangladesh |
| 121,544 | Saint John | | Canada |
| 22,679 | Saint John's | | Antigua and Barbuda |
| 48,841 | Saint-André | | Reunion |
| 34,856 | Saint-Benoît | | Reunion |
| 44,265 | Saint-Brieuc | | France |
| 36,287 | Saint-Chamond | | France |
| 10,757 | Saint-Claude | | Guadeloupe |
| 140,415 | Saint-Denis | | Reunion |
| 84,097 | Saint-Denis | | France |
| 23,340 | Sainte-Anne | | Guadeloupe |
| 286 | Saint-Élie | | French Guiana |
| 30,772 | Sainte-Marie | | Reunion |
| 19,830 | Sainte-Rose | | Guadeloupe |
| 7,057 | Sainte-Rose | | Reunion |
| 20,200 | Sainte-Suzanne | | Reunion |
| 172,125 | Saint-Étienne | | France |
| 12,297 | Saint-François | | Guadeloupe |
| 2,628 | Saint-Georges | | French Guiana |
| 42,817 | Saint-Gilles | Sint-Gillis | Belgium |
| 49,608 | Saint-Hyacinthe | | Canada |
| 81,969 | Saint-Jean-sur-Richelieu | | Canada |
| 33,104 | Saint-Joseph | | Reunion |
| 27,429 | Saint-Laurent-du-Maroni | | French Guiana |
| 28,320 | Saint-Leu | | Reunion |
| 130,750 | Saint-Louis | | Senegal |
| 48,492 | Saint-Louis | | Reunion |
| 2,809 | Saint-Louis | | Guadeloupe |
| 52,229 | Saint-Malo | | France |
| 64,539 | Saint-Marc | | Haiti |
| 70,552 | Saint-Maur-des-Fossés | | France |
| 64,750 | Saint-Nazaire | | France |
| 68,566 | Saint-Nicolas | Sint-Niklaas | Belgium |
| 15,788 | Saint-Omer | | France |
| 100,849 | Saint-Paul | | Reunion |
| 5,448 | Saint-Philippe | | Reunion |
| 76,900 | Saint-Pierre | | Reunion |
| 57,082 | Saint-Quentin | | France |
| 37,404 | Saint-Trond | Sint-Truiden | Belgium |
| 55,250 | Sajanogorsk | | Russia |
| 44,395 | Sajansk | | Russia |
| 21,070 | Sajnšand | | Mongolia |
400 | 785,468 | Sakai | | Japan |
| 88,441 | Sakakah | | Saudi Arabia |
| 21,197 | Sakaraha | | Madagascar |
| 30,111 | Sakété | | Benin |
| 23,861 | Sakhnin | | Israel |
| 123,842 | Saki | | Nigeria |
| 103,442 | Sakon Nakhon | | Thailand |
| 356,449 | Sakonika | Thessaloníki | Greece |
| 50,963 | Sakta | | Bangladesh |
| 183,491 | Sakura | | Japan |
| 1,684 | Sal Rei | | Cape Verde |
| 21,706 | Sala | | Sweden |
| 24,520 | Šal'a | | Slovakia |
| 8,028 | Sala Krau | | Cambodia |
| 24,972 | Saladillo | | Argentina |
| 159,491 | Salalah | | Oman |
| 14,777 | Salamá | | Guatemala |
| 154,468 | Salamanca | | Spain |
| 149,439 | Salamanca | | Mexico |
| 27,468 | Salamís | | Greece |
| 19,292 | Salaspils | | Latvia |
| 185,488 | Salatiga | | Indonesia |
| 160,893 | Salavat | | Russia |
| 7,758 | Salazie | | Reunion |
| 11,141 | Salcajá | | Guatemala |
| 14,828 | Salcedo | | Dominican Republic |
| 43,861 | Saldanha | | South Africa |
| 12,950 | Saldus | | Latvia |
| 54,758 | Sale | | England |
| 38,315 | Salechard | | Russia |
354 | 885,176 | Salem | | India |
| 146,971 | Salem | | United States of America |
| 135,334 | Salerno | | Italy |
| 9,798 | Salfit | | Palestine |
| 69,085 | Salford | | England |
| 44,168 | Salgótarjan | | Hungary |
| 43,625 | Šali | | Russia |
| 89,860 | Salihli | | Turkey |
| 117,045 | Salihorsk | Soligorsk | Belarus |
| 22,440 | Salima | | Malawi |
| 39,526 | Salimpur | | Bangladesh |
| 83,674 | Salina Cruz | | Mexico |
| 152,149 | Salinas | | United States of America |
| 30,792 | Salinas | | Ecuador |
| 6,123 | Salinas | | Puerto Rico |
| 112,595 | Salisbury | | Australia |
| 44,653 | Salisbury | | England |
| 80,595 | Salmas | | Iran |
| 25,061 | Salo | | Finland |
| 37,859 | Salon-de-Provence | | France |
| 62,307 | Sal'sk | | Russia |
| 181,224 | Salt Lake City | | United States of America |
706 | 503,693 | Salta | | Argentina |
495 | 666,008 | Saltillo | | Mexico |
| 103,622 | Salto | | Uruguay |
| 24,675 | Salto | | Argentina |
| 6,663 | Salto del Guairá | | Paraguay |
73 | 2,621,530 | Salvador | | Brazil |
| 49,861 | Salwa | | Kuwait |
| 38,178 | Salyan | | Azerbaijan |
| 143,259 | Salzburg | | Austria |
| 111,378 | Salzgitter | | Germany |
| 39,627 | Sam Phram | | Thailand |
| 45,483 | Sama'il | | Oman |
| 55,293 | Samalkota | | India |
| 87,983 | Samalut | | Egypt |
| 14,203 | Samaná | Santa Bárbara de Samaná | Dominican Republic |
| 36,875 | Samandag | | Turkey |
515 | 641,383 | Samarinda | | Indonesia |
| 366,015 | Samarkand | Samarqand | Uzbekistan |
| 58,750 | Samastipur | | India |
| 29,517 | Samaxi | | Azerbaijan |
| 164,042 | Sambalpur | | India |
| 31,069 | Sambava | | Madagascar |
| 196,942 | Sambhal | | India |
| 26,951 | Sambreville | | Belgium |
| 69,521 | Sambrial | | Pakistan |
| 73,693 | Samcheok | Samch'ok | South Korea |
| 17,829 | Same | | Tanzania |
| 37,144 | Sämkir | | Azerbaijan |
| 84,550 | Sammundri | | Pakistan |
| 15,727 | Samobor | | Croatia |
| 27,749 | Samokov | | Bulgaria |
| 58,647 | Sampang | | Indonesia |
| 52,506 | Sampit | | Indonesia |
| 25,262 | Sâmraông | | Cambodia |
| 416,033 | Samsun | | Turkey |
| 28,832 | Samtredia | | Georgia |
178 | 1,473,521 | Samut Prakan | | Thailand |
| 84,518 | Samut Sakhon | | Thailand |
| 34,932 | Samut Songkhram | | Thailand |
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