Urban Area Rank City Pop Rank City Country City Population Urban Area Population 128 83 Havana Cuba 2328000 2662300 749 537 Santiago de Cuba Cuba 544400 544400 1033 901 Camaguey Cuba 348600 348600 1128 1019 Holguin Cuba 312100 312100 1280 1195 Guantanamo Cuba 269200 269200 1380 1307 Santa Clara Cuba 247800 247800 1809 1775 Bayamo Cuba 186400 186400 1901 1873 Pinar del Rio Cuba 176300 176300 1973 1944 Cienfuegos Cuba 168600 168600 2248 2229 Las Tunas Cuba 145800 145800 2300 2282 Matanzas Cuba 142200 142200 2607 2591 Sancti Spiritus Cuba 123200 123200 2658 2642 Manzanillo Cuba 121000 121000 2681 2665 Ciego de Avila Cuba 119800 119800 2862 2846 Palma Soriano Cuba 111600 111600